Effects of radiosensitization on proliferation-related events in Ehrlich ascites tumour cells

Abstract

Ehrlich ascites tumor cell damage after ionizing radiation (2 Gy) and radiosensitization (HPde 2 Gy) was investigated. According to the data obtained, 2 Gy induced 7% of multinuclear cells, 15% inhibited DNA synthesis, but no significant apoptosis/necrosis was observed after tiese cell injuries. After radiosensitization (HPde 2 Gy) the number of multinuclear celės did not change, whereas DNA synthesis was inhibited up to 48% and mostly dead EAT cells were detected. Key words: hematoporphyrin dimethyl ether, photodynamic therapy, Ehrlich ascites tumor Keywords: Hpde – hematoporphyrin dimethyl ether, PDT – photodynamic therapy, EAT – Ehrlich ascites tumor