Evaluation of compatibility of FluidCrystal® formulations with fibre-type hemp (Cannabis sativa L.) extracts

Aušra Linkevičiūtė-Dumčė; Jurga Būdienė; Jenni Engstedt; Justas Barauskas

doi:10.6001/chemija.2025.36.1.6

Aušra Linkevičiūtė-Dumčė
Jurga Būdienė
Jenni Engstedt
Justas Barauskas

DOI: https://doi.org/10.6001/chemija.2025.36.1.6

Keywords: phytocannabinoids, Cannabis sativa, lipid liquid crystals, lipid-based delivery systems, small-angle X-ray diffraction, antioxidant

Abstract

The main objective of the present study was to investigate mixtures of soy phosphatidylcholine (SPC) and glycerol dioleate (GDO) as encapsulation matrices for Cannabis sativa L. phytocannabinoids. The effects of cannabinoids loading into non-aqueous formulations and non-lamellar liquid crystalline phases were studied using synchrotron small-angle X-ray diffraction and dynamic light scattering methods. The incorporation of phytocannabinoids is discussed with respect to the lipid aggregation behaviour, self-assembled nanostructures, and long-term chemical stability. The obtained results showed that SPC/GDO-based formulations can incorporate relatively high amounts of cannabinoids and could serve as liquid crystalline delivery vehicles in the form of bulk phases.