Quantitative determination of the new substance 7-(4-fluorobenzyl)-3-thioxo-2,3-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one as a potential pharmaceutical agent

  • Krystyna Netosova
  • Oksana Zavada
  • Anna Materiienko
  • Iryna Zhuravel
  • Serhii Baiurka
Keywords: quantification, potentiometric titration, [1,2,4]triazolo[4,3-А]pyrazin-8-ones, analytical validation


The article presents results of studies on the development of a quantification method for a substance 7-(4-fluorobenzyl)-3-thioxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one using the method of nonaqueous potentiometric titration. Validation of the developed method has been carried out confirming the following characteristics: linearity, accuracy and precision that match the acceptance criteria for these measures.
Organic Chemistry