The effect of methanesulfonylhydrazine and its hydrazones on yeast Saccharomyces cerevisiae viability

Abstract

Three cytotoxic Schiff bases, previously synthesized by us: salicylaldehyde methanesulfonylhydrazone, 2-hydroxyacetophenone methanesulfonylhydrazone and 2-hydroxy-1-naphthaldehyde methanesulfonylhydrazone, along with acetone methanesulfonylhydrazone and the parent compound, methanesulfonylhydrazine, have been tested for their effect on Saccharomyces cerevisiae. All five compounds exhibited moderate antiyeast activity. The effect of the compounds on cell cycle and DNA integrity have been studied by FACS anglysis and Comet Assay. The compounds do not block the cells in a specific checkpoint and do not cause breaks in DNA. Keywords: methanesulfonylhydrazones, Saccharomyces cerevisiae, FACS analysis, Comet Assay